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Understanding mTOR Regulation to Develop Exercise Training Programs

John L. Ivy, PhD ©2014

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In this free webinar, John Ivy, PhD, describes how understanding protein synthesis can help professionals develop more effective exercise training programs. The adaptive response to exercise requires the activation of protein synthesis, which is closely regulated by the large protein kinase enzyme commonly known as mTOR and signaled through the multiprotein complex TORC1. TORC1 activity is influenced by growth factors (such as insulin), nutritional and energy status of the cell, and muscle contraction.

This presentation describes the regulation of TORC1 and its signaling pathway as well as the role of TORC1’s target proteins in the regulation of mRNA translation initiation. Also discussed is the influence of nutrition, cell environment, and exercise on TORC1 activity and how this information may help in developing the most expedient and beneficial exercise training programs.

John L. Ivy, PhD, is the Teresa Lozano Long endowed chair emeritus at the University of Texas at Austin. He received his doctorate in exercise physiology from the University of Maryland and trained in physiology and metabolism at Washington University School of Medicine as an NIH postdoctoral fellow. He served on the faculty at the University of Texas for 31 years and as chair of the department of kinesiology and health education for 13 years. Dr. Ivy is the author of more than 170 scientific papers, numerous book chapters, and four books on sport nutrition. His research has pioneered our understanding of muscle metabolism and how nutritional supplementation can improve exercise performance, recovery, and training adaptation. His research has also focused on the effects of exercise and nutrition on muscle glucose transport and insulin resistance and how diet and appropriate levels of physical activity can prevent type 2 diabetes and other metabolic diseases. Dr. Ivy is a fellow of the National Academy of Kinesiology and the American College of Sports Medicine and a recipient of the ACSM’s Citation Award. He is also a member of the American Physiological Society, American College of Nutrition, and Collegiate and Professional Sports Dietitians Association.