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Skeletal Muscle Damage and Repair PDF

Skeletal Muscle Damage and Repair PDF

$72.00 USD


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    Professionals and students interested in understanding the physiological mechanisms of skeletal muscle damage and repair will welcome this uniquely comprehensive text. Presenting both research-based information and applied clinical topics, Skeletal Muscle Damage and Repair assists readers in understanding the interrelationships of basic physiology, specific populations, and practical treatments for muscle injury and damage. The text covers a broad spectrum of topics:

    • The basic science and scientific methods used to investigate exercise-related muscle damage and repair

    • A review of current research related to the mechanisms of muscle damage, physiological responses to damage, and subsequent methods of muscle repair

    • An examination of issues specific to various populations, including the elderly, diabetics, people with muscular dystrophies, and elite athletes

    • An evaluation of other practical topics as they apply to muscle damage and repair, such as gender and hormonal influences, effects on gait mechanics, the impact in workplace settings, and the issue of “high-responder” individuals who seem extraordinarily susceptible to muscle damage

    • A critical analysis of the efficacy of various popular treatment modalities, including massage, ultrasound, trigger-point therapy, physical therapy, nutraceutical interventions, and hyperbaric oxygen treatment

    The text is organized into 21 chapters, each written by an internationally acclaimed researcher or research group who are experts in their field. Chapters are grouped into three parts covering a wide range of both current research and clinical topics related to skeletal muscle damage and repair mechanisms and their applications. Part I presents the physical mechanisms of muscle damage, inflammation, and repair. Part II addresses muscle damage and repair mechanisms and issues in specific populations, including older adults, diabetics, and athletes. Part III considers the influences of treatment interventions on muscle repair and healing. The combination of the three parts culminates in a thorough understanding of muscle damage and repair.

    Skeletal Muscle Damage and Repair promotes an understanding of the physiological mechanisms of skeletal muscle damage and repair vital for many health professionals, therapists, kinesiologists, and physical educators. This comprehensive text exposes professionals, clinicians, and researchers to a range of issues related to muscle damage and repair. It also encourages communication between researchers interested in the mechanisms of muscle damage and repair and practitioners who treat muscle injury in various populations.

    Part I. Physiology of Muscle Damage and Repair

    Chapter 1. Physiology and Mechanisms of Skeletal Muscle Damage

    Timothy J. Koh, PhD


    Fiber Type and Injury

    Mechanisms of Muscle Injury

    Nature of Exercise-Induced Muscle Injury


    Chapter 2. Human and Animal Experimental Muscle Injury Models

    Gordon L. Warren, PhD, and Leigh E. Palubinskas, MS

    Human Muscle Injury Models

    Animal Muscle Injury Models


    Chapter 3. Histological, Chemical, and Functional Manifestations of Muscle Damage

    Stephen P. Sayers, PhD, and Monica J. Hubal, PhD

    Histological Evidence of Muscle Damage

    Biochemical and Histochemical Evidence of Muscle Damage

    Functional Evidence of Muscle Damage


    Chapter 4. Neutrophils and Macrophages in Muscle Damage and Repair

    Francis X. Pizza, PhD

    The Timing and Mechanism of Neutrophil and Macrophage Accumulation

    The Causative Factors in Neutrophil and Macrophage Accumulation

    Neutrophil- and Macrophage-Induced Injury

    Neutrophil- and Macrophage-Assisted Muscle Repair


    Chapter 5. Muscle Soreness and Damage and the Repeated-Bout Effect

    Ken Nosaka, PhD

    Muscle Soreness

    DOMS and Muscle Damage

    Repeated-Bout Effect


    Chapter 6. Satellite Cells and Muscle Repair

    Karin Shortreed, BS; Adam Johnston, BS; and Thomas Hawke, PhD

    Skeletal Muscle Stem Cell Populations

    Muscle Repair and the Myogenic Satellite Cell

    Extrinsic Regulation of Myogenic Satellite Cells

    Special Populations, Therapies, and Myogenic Satellite Cells


    Chapter 7. Emerging Molecular Trends in Muscle Damage Research

    Douglas J. Mahoney, PhD, and Mark A. Tarnopolsky, MD, PhD

    The “Omic” Revolution

    Gene Expression

    Transcriptomic Technology

    Limitations of DNA Microarray Muscle Damage Study

    The Future of Omics in Muscle Damage Research


    Part II. Muscle Damage and Repair in Applied Situations

    Chapter 8. Changes With Aging

    Susan V. Brooks, PhD

    Physical Frailty

    Contraction-Induced Injury

    Increasing Resistance to Contraction-Induced Injury


    Chapter 9. Duchenne Muscular Dystrophy

    Tommy G. Grainer, MS; Qiong Wang, MS; Christopher W. Ward, PhD; and Robert W. Grange, PhD


    Dystrophin Structure, Glycoprotein Complex, and Gene

    Scientific Investigation

    Issues for Investigation


    Chapter 10. Estrogen and Gender Effects

    Peter M. Tiidus, PhD

    Estrogen Effects on Tissues

    Estrogen Effects on Skeletal Muscle Damage

    Reduction of Postexercise Inflammatory Response

    Possible Influence of Estrogen on Skeletal Muscle Repair


    Chapter 11. Diabetes

    Lisa Stenho-Bittel, PhD, PT; Muhammel Al-Jarrah, PhD, PT; and S. Janette Williams

    Alterations in Glucose Transport

    Diabetes and Oxidative Stress

    Fatty Acid Metabolism

    Extracellular Matrix Changes

    Vascular Complications



    Chapter 12. Workplace and Other Overuse Injuries

    Mary F. Barbe, PhD, and Ann E. Barr, PT, PhD

    Muscle Response to Injuries

    Workplace- and Overuse-Related Muscular Disorders

    Potential Interventions


    Chapter 13. Muscle Function During Human Gait

    Michael Pierrynowski, PhD

    Characterizing Muscle Function

    Measuring Muscle Function During Gait

    Muscle Function During Normal Gait

    Impact of Muscle Damage on Gait


    Chapter 14. Overtraining Injuries in Athletic Populations

    Teet Seene, PhD; Maria Umnova, PhD; Priit Kaasik, PhD; Karin Alev, PhD; and Ando Pehme, PhD

    Insufficient Recovery and Overload

    Overtraining Effects on Skeletal Muscle

    Changes in Skeletal Muscle Biochemistry

    Protein Isoforms


    Chapter 15. Intersubject Variability in Developing Exertional Muscle Damage

    Priscilla M. Clarkson, PhD, and Stephen P. Sayers, PhD

    Factors Affecting Development of Rhabdomyolysis

    Variability in Responses to Eccentric Exercise

    Genetic Differences in High Responders


    Part III. Treatments and Interventions in Muscle Damage and Repair

    Chapter 16. Massage Therapy

    Peter M. Tiidus, PhD

    Massage Effects on Indirect Indices of Damage and Repair

    Massage Effects on Fibrosis, Muscle Tension, and Mood


    Chapter 17. Ultrasound

    Dawn A. Gulick, PhD, PT

    Mechanisms of Ultrasound

    Effects of Ultrasound on Tissue

    Phonophoresis (or Sonophoresis)



    Chapter 18. Physical Therapy and Related Interventions

    Richard M. Lovering, PhD, PT

    Muscle Injury and Recovery

    Types of Muscle Injury

    Current Therapies



    Chapter 19. Antioxidant Supplementation

    Allan H. Goldfarb, PhD

    Potential Mechanisms of Exercise-Induced Muscle Damage

    Vitamin Supplementation

    Supplementation with Other Antioxidants

    Combined Antioxidant Supplementation


    Chapter 20. Therapies for Myofascial Trigger Points

    Leesa K. Huguenin, MBBS, MS

    Defining and Explaining Trigger Points

    Investigating Trigger Points

    Proposed therapies


    Chapter 21. Hyperbaric Oxygen and Drug Therapies

    Peter M. Tiidus, PhD

    Hyperbaric Oxygen Therapy

    Drug Therapies


    Peter M. Tiidus, PhD, is a professor and the department chair of the department of kinesiology and physical education at Wilfrid Laurier University in Waterloo, Ontario, Canada. For more than 20 years he has focused his research on the physiological mechanisms of and practical interventions in muscle damage and repair, employing both animal models and human subjects.

    Tiidus has authored more than 60 publications and presented his research in more than 80 lectures and conference presentations on the topics of estrogen and muscle damage, inflammation, and repair and the influence of treatment interventions on muscle recovery from damage and physiological responses. He currently serves as an editorial board member for Medicine and Science in Sports and Exercise. He is also a former member of the board of directors of the Canadian Society for Exercise Physiology.

    A former competitive swimmer and swim coach, Tiidus continues to enjoy swimming as well as cycling, skiing, and reading. He and his wife, Ann, live in Waterloo, Ontario, Canada.

    “This book offers quality information on a very specific aspect of muscle performance. Few if any other books focus on such a defined area.”

    -Doody’s Book Review

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