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Skeletal Muscle Damage and Repair PDF

Author: Peter Tiidus

$72.00 USD

eBook
$72.00 USD

ISBN: 9781492575498

©2008

Page Count: 352

Access Duration: 10 Years

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Professionals and students interested in understanding the physiological mechanisms of skeletal muscle damage and repair will welcome this uniquely comprehensive text. Presenting both research-based information and applied clinical topics, Skeletal Muscle Damage and Repair assists readers in understanding the interrelationships of basic physiology, specific populations, and practical treatments for muscle injury and damage. The text covers a broad spectrum of topics:

• The basic science and scientific methods used to investigate exercise-related muscle damage and repair

• A review of current research related to the mechanisms of muscle damage, physiological responses to damage, and subsequent methods of muscle repair

• An examination of issues specific to various populations, including the elderly, diabetics, people with muscular dystrophies, and elite athletes

• An evaluation of other practical topics as they apply to muscle damage and repair, such as gender and hormonal influences, effects on gait mechanics, the impact in workplace settings, and the issue of “high-responder” individuals who seem extraordinarily susceptible to muscle damage

• A critical analysis of the efficacy of various popular treatment modalities, including massage, ultrasound, trigger-point therapy, physical therapy, nutraceutical interventions, and hyperbaric oxygen treatment

The text is organized into 21 chapters, each written by an internationally acclaimed researcher or research group who are experts in their field. Chapters are grouped into three parts covering a wide range of both current research and clinical topics related to skeletal muscle damage and repair mechanisms and their applications. Part I presents the physical mechanisms of muscle damage, inflammation, and repair. Part II addresses muscle damage and repair mechanisms and issues in specific populations, including older adults, diabetics, and athletes. Part III considers the influences of treatment interventions on muscle repair and healing. The combination of the three parts culminates in a thorough understanding of muscle damage and repair.

Skeletal Muscle Damage and Repair promotes an understanding of the physiological mechanisms of skeletal muscle damage and repair vital for many health professionals, therapists, kinesiologists, and physical educators. This comprehensive text exposes professionals, clinicians, and researchers to a range of issues related to muscle damage and repair. It also encourages communication between researchers interested in the mechanisms of muscle damage and repair and practitioners who treat muscle injury in various populations.

Part I. Physiology of Muscle Damage and Repair

Chapter 1. Physiology and Mechanisms of Skeletal Muscle Damage

Timothy J. Koh, PhD

Foundations

Fiber Type and Injury

Mechanisms of Muscle Injury

Nature of Exercise-Induced Muscle Injury

Summary

Chapter 2. Human and Animal Experimental Muscle Injury Models

Gordon L. Warren, PhD, and Leigh E. Palubinskas, MS

Human Muscle Injury Models

Animal Muscle Injury Models

Summary

Chapter 3. Histological, Chemical, and Functional Manifestations of Muscle Damage

Stephen P. Sayers, PhD, and Monica J. Hubal, PhD

Histological Evidence of Muscle Damage

Biochemical and Histochemical Evidence of Muscle Damage

Functional Evidence of Muscle Damage

Summary

Chapter 4. Neutrophils and Macrophages in Muscle Damage and Repair

Francis X. Pizza, PhD

The Timing and Mechanism of Neutrophil and Macrophage Accumulation

The Causative Factors in Neutrophil and Macrophage Accumulation

Neutrophil- and Macrophage-Induced Injury

Neutrophil- and Macrophage-Assisted Muscle Repair

Summary

Chapter 5. Muscle Soreness and Damage and the Repeated-Bout Effect

Ken Nosaka, PhD

Muscle Soreness

DOMS and Muscle Damage

Repeated-Bout Effect

Summary

Chapter 6. Satellite Cells and Muscle Repair

Karin Shortreed, BS; Adam Johnston, BS; and Thomas Hawke, PhD

Skeletal Muscle Stem Cell Populations

Muscle Repair and the Myogenic Satellite Cell

Extrinsic Regulation of Myogenic Satellite Cells

Special Populations, Therapies, and Myogenic Satellite Cells

Summary

Chapter 7. Emerging Molecular Trends in Muscle Damage Research

Douglas J. Mahoney, PhD, and Mark A. Tarnopolsky, MD, PhD

The “Omic” Revolution

Gene Expression

Transcriptomic Technology

Limitations of DNA Microarray Muscle Damage Study

The Future of Omics in Muscle Damage Research

Summary

Part II. Muscle Damage and Repair in Applied Situations

Chapter 8. Changes With Aging

Susan V. Brooks, PhD

Physical Frailty

Contraction-Induced Injury

Increasing Resistance to Contraction-Induced Injury

Summary

Chapter 9. Duchenne Muscular Dystrophy

Tommy G. Grainer, MS; Qiong Wang, MS; Christopher W. Ward, PhD; and Robert W. Grange, PhD

Overview

Dystrophin Structure, Glycoprotein Complex, and Gene

Scientific Investigation

Issues for Investigation

Summary

Chapter 10. Estrogen and Gender Effects

Peter M. Tiidus, PhD

Estrogen Effects on Tissues

Estrogen Effects on Skeletal Muscle Damage

Reduction of Postexercise Inflammatory Response

Possible Influence of Estrogen on Skeletal Muscle Repair

Summary

Chapter 11. Diabetes

Lisa Stenho-Bittel, PhD, PT; Muhammel Al-Jarrah, PhD, PT; and S. Janette Williams

Alterations in Glucose Transport

Diabetes and Oxidative Stress

Fatty Acid Metabolism

Extracellular Matrix Changes

Vascular Complications

Exercise

Summary

Chapter 12. Workplace and Other Overuse Injuries

Mary F. Barbe, PhD, and Ann E. Barr, PT, PhD

Muscle Response to Injuries

Workplace- and Overuse-Related Muscular Disorders

Potential Interventions

Summary

Chapter 13. Muscle Function During Human Gait

Michael Pierrynowski, PhD

Characterizing Muscle Function

Measuring Muscle Function During Gait

Muscle Function During Normal Gait

Impact of Muscle Damage on Gait

Summary

Chapter 14. Overtraining Injuries in Athletic Populations

Teet Seene, PhD; Maria Umnova, PhD; Priit Kaasik, PhD; Karin Alev, PhD; and Ando Pehme, PhD

Insufficient Recovery and Overload

Overtraining Effects on Skeletal Muscle

Changes in Skeletal Muscle Biochemistry

Protein Isoforms

Summary

Chapter 15. Intersubject Variability in Developing Exertional Muscle Damage

Priscilla M. Clarkson, PhD, and Stephen P. Sayers, PhD

Factors Affecting Development of Rhabdomyolysis

Variability in Responses to Eccentric Exercise

Genetic Differences in High Responders

Summary

Part III. Treatments and Interventions in Muscle Damage and Repair

Chapter 16. Massage Therapy

Peter M. Tiidus, PhD

Massage Effects on Indirect Indices of Damage and Repair

Massage Effects on Fibrosis, Muscle Tension, and Mood

Summary

Chapter 17. Ultrasound

Dawn A. Gulick, PhD, PT

Mechanisms of Ultrasound

Effects of Ultrasound on Tissue

Phonophoresis (or Sonophoresis)

Efficacy

Summary

Chapter 18. Physical Therapy and Related Interventions

Richard M. Lovering, PhD, PT

Muscle Injury and Recovery

Types of Muscle Injury

Current Therapies

Prevention

Summary

Chapter 19. Antioxidant Supplementation

Allan H. Goldfarb, PhD

Potential Mechanisms of Exercise-Induced Muscle Damage

Vitamin Supplementation

Supplementation with Other Antioxidants

Combined Antioxidant Supplementation

Summary

Chapter 20. Therapies for Myofascial Trigger Points

Leesa K. Huguenin, MBBS, MS

Defining and Explaining Trigger Points

Investigating Trigger Points

Proposed therapies

Summary

Chapter 21. Hyperbaric Oxygen and Drug Therapies

Peter M. Tiidus, PhD

Hyperbaric Oxygen Therapy

Drug Therapies

Summary

Peter M. Tiidus, PhD, is a professor and the department chair of the department of kinesiology and physical education at Wilfrid Laurier University in Waterloo, Ontario, Canada. For more than 20 years he has focused his research on the physiological mechanisms of and practical interventions in muscle damage and repair, employing both animal models and human subjects.

Tiidus has authored more than 60 publications and presented his research in more than 80 lectures and conference presentations on the topics of estrogen and muscle damage, inflammation, and repair and the influence of treatment interventions on muscle recovery from damage and physiological responses. He currently serves as an editorial board member for Medicine and Science in Sports and Exercise. He is also a former member of the board of directors of the Canadian Society for Exercise Physiology.

A former competitive swimmer and swim coach, Tiidus continues to enjoy swimming as well as cycling, skiing, and reading. He and his wife, Ann, live in Waterloo, Ontario, Canada.

“This book offers quality information on a very specific aspect of muscle performance. Few if any other books focus on such a defined area.”

-Doody’s Book Review

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Peter Tiidus

Skeletal Muscle Damage and Repair PDF

$72.00 USD

Professionals and students interested in understanding the physiological mechanisms of skeletal muscle damage and repair will welcome this uniquely comprehensive text. Presenting both research-based information and applied clinical topics, Skeletal Muscle Damage and Repair assists readers in understanding the interrelationships of basic physiology, specific populations, and practical treatments for muscle injury and damage. The text covers a broad spectrum of topics:

• The basic science and scientific methods used to investigate exercise-related muscle damage and repair

• A review of current research related to the mechanisms of muscle damage, physiological responses to damage, and subsequent methods of muscle repair

• An examination of issues specific to various populations, including the elderly, diabetics, people with muscular dystrophies, and elite athletes

• An evaluation of other practical topics as they apply to muscle damage and repair, such as gender and hormonal influences, effects on gait mechanics, the impact in workplace settings, and the issue of “high-responder” individuals who seem extraordinarily susceptible to muscle damage

• A critical analysis of the efficacy of various popular treatment modalities, including massage, ultrasound, trigger-point therapy, physical therapy, nutraceutical interventions, and hyperbaric oxygen treatment

The text is organized into 21 chapters, each written by an internationally acclaimed researcher or research group who are experts in their field. Chapters are grouped into three parts covering a wide range of both current research and clinical topics related to skeletal muscle damage and repair mechanisms and their applications. Part I presents the physical mechanisms of muscle damage, inflammation, and repair. Part II addresses muscle damage and repair mechanisms and issues in specific populations, including older adults, diabetics, and athletes. Part III considers the influences of treatment interventions on muscle repair and healing. The combination of the three parts culminates in a thorough understanding of muscle damage and repair.

Skeletal Muscle Damage and Repair promotes an understanding of the physiological mechanisms of skeletal muscle damage and repair vital for many health professionals, therapists, kinesiologists, and physical educators. This comprehensive text exposes professionals, clinicians, and researchers to a range of issues related to muscle damage and repair. It also encourages communication between researchers interested in the mechanisms of muscle damage and repair and practitioners who treat muscle injury in various populations.

Part I. Physiology of Muscle Damage and Repair

Chapter 1. Physiology and Mechanisms of Skeletal Muscle Damage

Timothy J. Koh, PhD

Foundations

Fiber Type and Injury

Mechanisms of Muscle Injury

Nature of Exercise-Induced Muscle Injury

Summary

Chapter 2. Human and Animal Experimental Muscle Injury Models

Gordon L. Warren, PhD, and Leigh E. Palubinskas, MS

Human Muscle Injury Models

Animal Muscle Injury Models

Summary

Chapter 3. Histological, Chemical, and Functional Manifestations of Muscle Damage

Stephen P. Sayers, PhD, and Monica J. Hubal, PhD

Histological Evidence of Muscle Damage

Biochemical and Histochemical Evidence of Muscle Damage

Functional Evidence of Muscle Damage

Summary

Chapter 4. Neutrophils and Macrophages in Muscle Damage and Repair

Francis X. Pizza, PhD

The Timing and Mechanism of Neutrophil and Macrophage Accumulation

The Causative Factors in Neutrophil and Macrophage Accumulation

Neutrophil- and Macrophage-Induced Injury

Neutrophil- and Macrophage-Assisted Muscle Repair

Summary

Chapter 5. Muscle Soreness and Damage and the Repeated-Bout Effect

Ken Nosaka, PhD

Muscle Soreness

DOMS and Muscle Damage

Repeated-Bout Effect

Summary

Chapter 6. Satellite Cells and Muscle Repair

Karin Shortreed, BS; Adam Johnston, BS; and Thomas Hawke, PhD

Skeletal Muscle Stem Cell Populations

Muscle Repair and the Myogenic Satellite Cell

Extrinsic Regulation of Myogenic Satellite Cells

Special Populations, Therapies, and Myogenic Satellite Cells

Summary

Chapter 7. Emerging Molecular Trends in Muscle Damage Research

Douglas J. Mahoney, PhD, and Mark A. Tarnopolsky, MD, PhD

The “Omic” Revolution

Gene Expression

Transcriptomic Technology

Limitations of DNA Microarray Muscle Damage Study

The Future of Omics in Muscle Damage Research

Summary

Part II. Muscle Damage and Repair in Applied Situations

Chapter 8. Changes With Aging

Susan V. Brooks, PhD

Physical Frailty

Contraction-Induced Injury

Increasing Resistance to Contraction-Induced Injury

Summary

Chapter 9. Duchenne Muscular Dystrophy

Tommy G. Grainer, MS; Qiong Wang, MS; Christopher W. Ward, PhD; and Robert W. Grange, PhD

Overview

Dystrophin Structure, Glycoprotein Complex, and Gene

Scientific Investigation

Issues for Investigation

Summary

Chapter 10. Estrogen and Gender Effects

Peter M. Tiidus, PhD

Estrogen Effects on Tissues

Estrogen Effects on Skeletal Muscle Damage

Reduction of Postexercise Inflammatory Response

Possible Influence of Estrogen on Skeletal Muscle Repair

Summary

Chapter 11. Diabetes

Lisa Stenho-Bittel, PhD, PT; Muhammel Al-Jarrah, PhD, PT; and S. Janette Williams

Alterations in Glucose Transport

Diabetes and Oxidative Stress

Fatty Acid Metabolism

Extracellular Matrix Changes

Vascular Complications

Exercise

Summary

Chapter 12. Workplace and Other Overuse Injuries

Mary F. Barbe, PhD, and Ann E. Barr, PT, PhD

Muscle Response to Injuries

Workplace- and Overuse-Related Muscular Disorders

Potential Interventions

Summary

Chapter 13. Muscle Function During Human Gait

Michael Pierrynowski, PhD

Characterizing Muscle Function

Measuring Muscle Function During Gait

Muscle Function During Normal Gait

Impact of Muscle Damage on Gait

Summary

Chapter 14. Overtraining Injuries in Athletic Populations

Teet Seene, PhD; Maria Umnova, PhD; Priit Kaasik, PhD; Karin Alev, PhD; and Ando Pehme, PhD

Insufficient Recovery and Overload

Overtraining Effects on Skeletal Muscle

Changes in Skeletal Muscle Biochemistry

Protein Isoforms

Summary

Chapter 15. Intersubject Variability in Developing Exertional Muscle Damage

Priscilla M. Clarkson, PhD, and Stephen P. Sayers, PhD

Factors Affecting Development of Rhabdomyolysis

Variability in Responses to Eccentric Exercise

Genetic Differences in High Responders

Summary

Part III. Treatments and Interventions in Muscle Damage and Repair

Chapter 16. Massage Therapy

Peter M. Tiidus, PhD

Massage Effects on Indirect Indices of Damage and Repair

Massage Effects on Fibrosis, Muscle Tension, and Mood

Summary

Chapter 17. Ultrasound

Dawn A. Gulick, PhD, PT

Mechanisms of Ultrasound

Effects of Ultrasound on Tissue

Phonophoresis (or Sonophoresis)

Efficacy

Summary

Chapter 18. Physical Therapy and Related Interventions

Richard M. Lovering, PhD, PT

Muscle Injury and Recovery

Types of Muscle Injury

Current Therapies

Prevention

Summary

Chapter 19. Antioxidant Supplementation

Allan H. Goldfarb, PhD

Potential Mechanisms of Exercise-Induced Muscle Damage

Vitamin Supplementation

Supplementation with Other Antioxidants

Combined Antioxidant Supplementation

Summary

Chapter 20. Therapies for Myofascial Trigger Points

Leesa K. Huguenin, MBBS, MS

Defining and Explaining Trigger Points

Investigating Trigger Points

Proposed therapies

Summary

Chapter 21. Hyperbaric Oxygen and Drug Therapies

Peter M. Tiidus, PhD

Hyperbaric Oxygen Therapy

Drug Therapies

Summary

Peter M. Tiidus, PhD, is a professor and the department chair of the department of kinesiology and physical education at Wilfrid Laurier University in Waterloo, Ontario, Canada. For more than 20 years he has focused his research on the physiological mechanisms of and practical interventions in muscle damage and repair, employing both animal models and human subjects.

Tiidus has authored more than 60 publications and presented his research in more than 80 lectures and conference presentations on the topics of estrogen and muscle damage, inflammation, and repair and the influence of treatment interventions on muscle recovery from damage and physiological responses. He currently serves as an editorial board member for Medicine and Science in Sports and Exercise. He is also a former member of the board of directors of the Canadian Society for Exercise Physiology.

A former competitive swimmer and swim coach, Tiidus continues to enjoy swimming as well as cycling, skiing, and reading. He and his wife, Ann, live in Waterloo, Ontario, Canada.

“This book offers quality information on a very specific aspect of muscle performance. Few if any other books focus on such a defined area.”

-Doody’s Book Review

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