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Skeletal Muscle Damage and Repair eBook

Skeletal Muscle Damage and Repair eBook

$72.00 USD

Available As


    Professionals and students interested in understanding the physiological mechanisms of skeletal muscle damage and repair will welcome this uniquely comprehensive text. Presenting both research-based information and applied clinical topics, Skeletal Muscle Damage and Repair assists readers in understanding the interrelationships of basic physiology, specific populations, and practical treatments for muscle injury and damage. The text covers a broad spectrum of topics:

      • The basic science and scientific methods used to investigate exercise-related muscle damage and repair
      • A review of current research related to the mechanisms of muscle damage, physiological responses to damage, and subsequent methods of muscle repair
      • An examination of issues specific to various populations, including the elderly, diabetics, people with muscular dystrophies, and elite athletes
      • An evaluation of other practical topics as they apply to muscle damage and repair, such as gender and hormonal influences, effects on gait mechanics, the impact in workplace settings, and the issue of “high-responder” individuals who seem extraordinarily susceptible to muscle damage
      • A critical analysis of the efficacy of various popular treatment modalities, including massage, ultrasound, trigger-point therapy, physical therapy, nutraceutical interventions, and hyperbaric oxygen treatment

    The text is organized into 21 chapters, each written by an internationally acclaimed researcher or research group who are experts in their field. Chapters are grouped into three parts covering a wide range of both current research and clinical topics related to skeletal muscle damage and repair mechanisms and their applications. Part I presents the physical mechanisms of muscle damage, inflammation, and repair. Part II addresses muscle damage and repair mechanisms and issues in specific populations, including older adults, diabetics, and athletes. Part III considers the influences of treatment interventions on muscle repair and healing. The combination of the three parts culminates in a thorough understanding of muscle damage and repair.

    Skeletal Muscle Damage and Repair promotes an understanding of the physiological mechanisms of skeletal muscle damage and repair vital for many health professionals, therapists, kinesiologists, and physical educators. This comprehensive text exposes professionals, clinicians, and researchers to a range of issues related to muscle damage and repair. It also encourages communication between researchers interested in the mechanisms of muscle damage and repair and practitioners who treat muscle injury in various populations.


    A reference for professionals in sports medicine and kinesiology-related fields, including skeletal muscle researchers, physical therapists, athletic trainers, and massage therapists. A textbook for muscle physiology and pathology courses dealing with musculoskeletal injury, therapeutic exercise and modalities, and management of soft-tissue injuries and diseases.

    Table of Contents

    Part I. Physiology of Muscle Damage and Repair

    Chapter 1. Physiology and Mechanisms of Skeletal Muscle Damage
    Timothy J. Koh, PhD
    Fiber Type and Injury
    Mechanisms of Muscle Injury
    Nature of Exercise-Induced Muscle Injury

    Chapter 2. Human and Animal Experimental Muscle Injury Models
    Gordon L. Warren, PhD, and Leigh E. Palubinskas, MS
    Human Muscle Injury Models
    Animal Muscle Injury Models

    Chapter 3. Histological, Chemical, and Functional Manifestations of Muscle Damage
    Stephen P. Sayers, PhD, and Monica J. Hubal, PhD
    Histological Evidence of Muscle Damage
    Biochemical and Histochemical Evidence of Muscle Damage
    Functional Evidence of Muscle Damage

    Chapter 4. Neutrophils and Macrophages in Muscle Damage and Repair
    Francis X. Pizza, PhD
    The Timing and Mechanism of Neutrophil and Macrophage Accumulation
    The Causative Factors in Neutrophil and Macrophage Accumulation
    Neutrophil- and Macrophage-Induced Injury
    Neutrophil- and Macrophage-Assisted Muscle Repair

    Chapter 5. Muscle Soreness and Damage and the Repeated-Bout Effect
    Ken Nosaka, PhD
    Muscle Soreness
    DOMS and Muscle Damage
    Repeated-Bout Effect

    Chapter 6. Satellite Cells and Muscle Repair
    Karin Shortreed, BS; Adam Johnston, BS; and Thomas Hawke, PhD
    Skeletal Muscle Stem Cell Populations
    Muscle Repair and the Myogenic Satellite Cell
    Extrinsic Regulation of Myogenic Satellite Cells
    Special Populations, Therapies, and Myogenic Satellite Cells

    Chapter 7. Emerging Molecular Trends in Muscle Damage Research
    Douglas J. Mahoney, PhD, and Mark A. Tarnopolsky, MD, PhD
    The “Omic” Revolution
    Gene Expression
    Transcriptomic Technology
    Limitations of DNA Microarray Muscle Damage Study
    The Future of Omics in Muscle Damage Research

    Part II. Muscle Damage and Repair in Applied Situations

    Chapter 8. Changes With Aging
    Susan V. Brooks, PhD
    Physical Frailty
    Contraction-Induced Injury
    Increasing Resistance to Contraction-Induced Injury

    Chapter 9. Duchenne Muscular Dystrophy
    Tommy G. Grainer, MS; Qiong Wang, MS; Christopher W. Ward, PhD; and Robert W. Grange, PhD
    Dystrophin Structure, Glycoprotein Complex, and Gene
    Scientific Investigation
    Issues for Investigation

    Chapter 10. Estrogen and Gender Effects
    Peter M. Tiidus, PhD
    Estrogen Effects on Tissues
    Estrogen Effects on Skeletal Muscle Damage
    Reduction of Postexercise Inflammatory Response
    Possible Influence of Estrogen on Skeletal Muscle Repair

    Chapter 11. Diabetes
    Lisa Stenho-Bittel, PhD, PT; Muhammel Al-Jarrah, PhD, PT; and S. Janette Williams
    Alterations in Glucose Transport
    Diabetes and Oxidative Stress
    Fatty Acid Metabolism
    Extracellular Matrix Changes
    Vascular Complications

    Chapter 12. Workplace and Other Overuse Injuries
    Mary F. Barbe, PhD, and Ann E. Barr, PT, PhD
    Muscle Response to Injuries
    Workplace- and Overuse-Related Muscular Disorders
    Potential Interventions

    Chapter 13. Muscle Function During Human Gait
    Michael Pierrynowski, PhD
    Characterizing Muscle Function
    Measuring Muscle Function During Gait
    Muscle Function During Normal Gait
    Impact of Muscle Damage on Gait

    Chapter 14. Overtraining Injuries in Athletic Populations
    Teet Seene, PhD; Maria Umnova, PhD; Priit Kaasik, PhD; Karin Alev, PhD; and Ando Pehme, PhD
    Insufficient Recovery and Overload
    Overtraining Effects on Skeletal Muscle
    Changes in Skeletal Muscle Biochemistry
    Protein Isoforms

    Chapter 15. Intersubject Variability in Developing Exertional Muscle Damage
    Priscilla M. Clarkson, PhD, and Stephen P. Sayers, PhD
    Factors Affecting Development of Rhabdomyolysis
    Variability in Responses to Eccentric Exercise
    Genetic Differences in High Responders

    Part III. Treatments and Interventions in Muscle Damage and Repair

    Chapter 16. Massage Therapy
    Peter M. Tiidus, PhD
    Massage Effects on Indirect Indices of Damage and Repair
    Massage Effects on Fibrosis, Muscle Tension, and Mood

    Chapter 17. Ultrasound
    Dawn A. Gulick, PhD, PT
    Mechanisms of Ultrasound
    Effects of Ultrasound on Tissue
    Phonophoresis (or Sonophoresis)

    Chapter 18. Physical Therapy and Related Interventions
    Richard M. Lovering, PhD, PT
    Muscle Injury and Recovery
    Types of Muscle Injury
    Current Therapies

    Chapter 19. Antioxidant Supplementation
    Allan H. Goldfarb, PhD
    Potential Mechanisms of Exercise-Induced Muscle Damage
    Vitamin Supplementation
    Supplementation with Other Antioxidants
    Combined Antioxidant Supplementation

    Chapter 20. Therapies for Myofascial Trigger Points
    Leesa K. Huguenin, MBBS, MS
    Defining and Explaining Trigger Points
    Investigating Trigger Points
    Proposed therapies

    Chapter 21. Hyperbaric Oxygen and Drug Therapies
    Peter M. Tiidus, PhD
    Hyperbaric Oxygen Therapy
    Drug Therapies

    About the Author

    Peter M. Tiidus, PhD, is a professor and the department chair of the department of kinesiology and physical education at Wilfrid Laurier University in Waterloo, Ontario, Canada. For more than 20 years he has focused his research on the physiological mechanisms of and practical interventions in muscle damage and repair, employing both animal models and human subjects.

    Tiidus has authored more than 60 publications and presented his research in more than 80 lectures and conference presentations on the topics of estrogen and muscle damage, inflammation, and repair and the influence of treatment interventions on muscle recovery from damage and physiological responses. He currently serves as an editorial board member for Medicine and Science in Sports and Exercise. He is also a former member of the board of directors of the Canadian Society for Exercise Physiology.

    A former competitive swimmer and swim coach, Tiidus continues to enjoy swimming as well as cycling, skiing, and reading. He and his wife, Ann, live in Waterloo, Ontario, Canada.


    “This book offers quality information on a very specific aspect of muscle performance. Few if any other books focus on such a defined area.”

    -Doody’s Book Review